You just add `/D "SQLITE_MAX_COLUMN=16384"` on your `CL` cli. You may also want to add [`/O2`](1) to make it fast too. But of course, having 16K columns is suspicious from a relational design POV :) [1]: https://docs.microsoft.com/en-us/cpp/build/reference/o1-o2-minimize-size-maximize-speed?view=msvc-160