I think that's likely to lead to grief. Unless you have been lax about giving Admin rights to sketchy programs, anything in an application directory or system directory should be of little concern with respect to what DLL your program will load. This is because of how DLL loading rules determine priority of locations where identically named DLLs might be found. Furthermore, your version issue will depend upon what version of SQLite.Interop.dll gets loaded when you load (or cause to be loaded) System.Data.SQLite.dll, which will not collide with SQLite3.dll, ever. If you want to see what version of System.Data.SQLite has been installed, take a look at the listing known as "Apps & Features" (run via WinKey-X menu.)