I think I do: my use case is downloading a binary copy of an existing SQLite DB from a data storage such as S3, where the copy naturally comes down as a blob of bytes. I could create a file, write the data there and open that as my DB, but I would rather deserialize the data directly into an in-memory DB. This not only avoids creating the file, it allows this use case to work even when there are no permissions / resources to create such a file. If I understood you correctly, simply enabling this flag causes potential performance impacts? Can you provide more details?