SQLite Forum

Is it safe to VACUUM on a new database connection?
Rowan replied very well to your question, but I'm alarmed that you have unexpected access.

Ignoring this new <code>VACUUM</code> you want to add, do you have one connection being used by many threads, or many connections ?

Have you set a timeout on every connection to the database ?  If not, you should do, and this will reduce access clashes.