Index: src/mutex.c
==================================================================
--- src/mutex.c
+++ src/mutex.c
@@ -73,10 +73,11 @@
 
 /*
 ** Initialize the mutex system.
 */
 int sqlite3MutexInit(void){ 
+  static int initPending = 0;
   int rc;
   if( sqlite3CompareAndSwap((void * volatile *)&sqlite3GlobalConfig.pMutex,
                    0, &sqlite3GlobalConfig.mutex)==0 || mutexIsInvalid() ){
     /* If the mutex implementation pointer has not been set, then the user
     ** did not install a mutex implementation via sqlite3_config() prior to
@@ -91,12 +92,16 @@
       pFrom = sqlite3NoopMutex();
     }
     mutexCopy(&sqlite3GlobalConfig.mutex, pFrom);
     sqlite3MemoryBarrier();
   }
-  assert( sqlite3GlobalConfig.mutex.xMutexInit );
-  rc = sqlite3GlobalConfig.mutex.xMutexInit();
+  if( !initPending ){
+    assert( sqlite3GlobalConfig.mutex.xMutexInit );
+    initPending = 1;
+    rc = sqlite3GlobalConfig.mutex.xMutexInit();
+    initPending = 0;
+  }
 
 #ifdef SQLITE_DEBUG
   GLOBAL(int, mutexIsInit) = 1;
 #endif