Index: src/global.c
==================================================================
--- src/global.c
+++ src/global.c
@@ -135,13 +135,20 @@
 ** using the SQLITE_USE_URI=1 or SQLITE_USE_URI=0 compile-time options.
 **
 ** EVIDENCE-OF: R-43642-56306 By default, URI handling is globally
 ** disabled. The default value may be changed by compiling with the
 ** SQLITE_USE_URI symbol defined.
+**
+** URI filenames are enabled by default if SQLITE_HAS_CODEC is
+** enabled.
 */
 #ifndef SQLITE_USE_URI
-# define  SQLITE_USE_URI 0
+# ifdef SQLITE_HAS_CODEC
+#  define SQLITE_USE_URI 1
+# else
+#  define SQLITE_USE_URI 0
+# endif
 #endif
 
 /* EVIDENCE-OF: R-38720-18127 The default setting is determined by the
 ** SQLITE_ALLOW_COVERING_INDEX_SCAN compile-time option, or is "on" if
 ** that compile-time option is omitted.

Index: src/main.c
==================================================================
--- src/main.c
+++ src/main.c
@@ -3093,20 +3093,22 @@
     sqlite3GlobalConfig.xSqllog(pArg, db, zFilename, 0);
   }
 #endif
 #if defined(SQLITE_HAS_CODEC)
   if( rc==SQLITE_OK ){
-    const char *zHexKey = sqlite3_uri_parameter(zOpen, "hexkey");
-    if( zHexKey && zHexKey[0] ){
+    const char *zKey;
+    if( (zKey = sqlite3_uri_parameter(zOpen, "hexkey"))!=0 && zKey[0] ){;
       u8 iByte;
       int i;
-      char zKey[40];
-      for(i=0, iByte=0; i<sizeof(zKey)*2 && sqlite3Isxdigit(zHexKey[i]); i++){
-        iByte = (iByte<<4) + sqlite3HexToInt(zHexKey[i]);
-        if( (i&1)!=0 ) zKey[i/2] = iByte;
+      char zDecoded[40];
+      for(i=0, iByte=0; i<sizeof(zDecoded)*2 && sqlite3Isxdigit(zKey[i]); i++){
+        iByte = (iByte<<4) + sqlite3HexToInt(zKey[i]);
+        if( (i&1)!=0 ) zDecoded[i/2] = iByte;
       }
-      sqlite3_key_v2(db, 0, zKey, i/2);
+      sqlite3_key_v2(db, 0, zDecoded, i/2);
+    }else if( (zKey = sqlite3_uri_parameter(zOpen, "key"))!=0 ){
+      sqlite3_key_v2(db, 0, zKey, sqlite3Strlen30(zKey));
     }
   }
 #endif
   sqlite3_free(zOpen);
   return rc & 0xff;