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Amalgamation file for specific extension
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No, that is not possible in the way you have stated it.  The amalgamation **is** the "entire SQLite".

I suspect the question you meant to ask is: Is it possible to compile the extensions separately, then load them into a separately compiled SQLite instance (or process using one)? To that, I would answer: Yes, provided that the extension load mechanism is not disabled by the compilation options used.