To add to Warren's already good reply - SQLite's ability to guarantee Database ACID requirements has very little to do with whether the file is physically on a Network storage or not (or a SAN for that matter), but rather depends on the process being fully in control of the locking mechanism for the DB file. With WAL this is achieved as Warren describes, and for other DB journal types it depends on the locking mechanism of the OS. So the most correct assessment would be: As long as All read/write control of DB connector processes originate from the same machine+OS, or rather, the same OS process space in memory (i.e. not different VM's that are merely on the same hardware), then you should not have any problem.