For 'Desktop' like systems, I don't think so, the last was probably 16 bit x86 (which some memory models had this characteristic), but there are embedded processors with Harvard Architectures with different size Function and Object pointers. I don't know if SQLite supports any of them. Note, there ARE still machines out there running 32-bit windows which will still run 16-bit programs, so it can be a bit of a question of how you define 'platform in common use.