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large blank areas on config files.
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These are generated by GNU Autoconf, so their format is not under direct control of the SQLite developers. See the Autoconf docs for details.

If you’re worried about space efficiency, Fossil compresses the content of the files it manages, so the extra space is already “deflated” out of those files on disk and when transferred over the network. The same is true of the distribution Zip files and tarballs.