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Virtual RDBMS over SQLite
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You didn't say what you were developing it in/for. 

I have a slim ODBC/Sqlite interface for Javascript

https://www.npmjs.com/package/sack.vfs

https://github.com/d3x0r/sack.vfs/blob/master/tutorial/tutorial-sqlite.md

Handles all the native types date, number, string, blob (typedArray), etc... has a small create table parser which can take a create table statement, create it if it doesn't exist, and update/add columns/indexes that are new... 

basically 1 open command, and 1 do SQL command command.