So I now tell users of rqlite to work around this limitation by a) creating a RAM-backed file system, and b) using a normal SQLite file for their database, but place the SQLite file on the RAM-backed file system. My docs: https://github.com/rqlite/rqlite/blob/master/DOC/PERFORMANCE.md#in-memory-database-limits Hopefully this makes sense. Testing by some of my users tells me it works fine.